Effectiveness of Tagetes patula against chronic nonbacterial prostatitis in rat model

The effectiveness of water decoction of Tagetes patula was studied against the chronic nonbacterial prostatitis in a rat model induced by estradiol subcutaneously in a castrated male rat. The low-dose decoction of T. patula significantly ameliorated the prostatitis. The low-dose of polysaccharide and supernatant constituent of T. patula decreased the levels of IL-1 beta, TNF-alpha , PSA, and EGF, and improved the levels of testosterone and dihydrotestosterone in vivo. Further, the chemical study indicated that flavonoids were predominant in the supernatant constituent of T. patula. The flavonoids and polysaccharides were the effective constituents against prostatitis and this effect may be mediated by keeping hormone balance and a down-regulation of the inflammatory mediator level of the prostate.