Cellular Perception and Static Magnetic Fields Active Penetration Depth for Pain Magnetotherapy

Cellular perception concerns the process by which stimulation induces events through mechanical signaling pathways, according to a sense order whose nature is discussed by epistemology: It is supposed that the signification base at the origin of the cell behavior answers to a "being-envelope" whose physical nature can be approached in topological thermodynamics terms. In joined cells with gap-junctions, sense order can be covered by the signaling effect of calcium waves. But as it is related to the cell functional status, it can explain the biphasic response of the cell behavior after exposure to Static Magnetic Fields, SMF. Four magnetobiological mechanisms solve the "kT paradox" about thermal agitation, (whose energy is 4 . 10(-21) at 310 degrees K): 1/ Magnetosomes; (endogenous ferromagnetic nanoparticles can have magnetic moments of 2 . 10(-15) JT(-1)). For ionic channels activation, these magnetosomes must operate two other kT independent mechanisms: 2/ Radicals' pair, and 3/ Interference in angular modes of proteins. A fourth mechanism is: 4/ Protons subsystems, (inducing topological evolution in the medium). In these mechanisms, the SMF determining parameter is magnetic flux density, or induction B: When comparing clinical trials results about pain relief by SMF, an active induction threshold of 0.5 mT is suggested. With the field decay from the magnet surface, when B is around 0.5 mT, the lateral field gradient, dB/dx, is far under its active threshold, thus secondary. Therapy must determine the SMF Active Penetration Depth from the skin surface, as compared to the tissue receptors depth. It depends on the magnet characteristics and setting.