Investigating genetic overlaps of the genetic factor differentiating schizophrenia from bipolar disorder with cognitive function and hippocampal volume

被引：4
|
作者：
Ohi, Kazutaka [1 ,2 ]
Muto, Yukimasa [3 ]
Takai, Kentaro [3 ]
Sugiyama, Shunsuke [3 ]
Shioiri, Toshiki [3 ]
机构：
[1] Gifu Univ, Dept Psycniatry, Grad Sch Med, Gifu, Japan
[2] Kanazawa Med Univ, Dept Gen Internal Med, Uchinada, Ishikawa, Japan
[3] Gifu Univ, Dept Psychiat, Grad Sch Med, Gifu, Japan
来源：
BJPSYCH OPEN | 2022年 / 8卷 / 01期
基金：
日本学术振兴会;
关键词：
Genetic correlation; schizophrenia; bipolar disorder; cognitive function; hippocampus;
D O I：
10.1192/bjo.2021.1086
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Schizophrenia and bipolar disorder display clinical similarities and dissimilarities. We investigated whether the genetic factor differentiating schizophrenia from bipolar disorder is genetically associated with cognitive phenotypes and hippocampal volumes. We revealed genetic overlaps of the genetic differentiating factor with low general cognitive ability, low childhood IQ, low educational attainment and reduced hippocampal volumes. The genetic correlations with low general cognitive ability and reduced hippocampal volumes were associated with risk of schizophrenia, whereas the genetic correlations with high childhood IQ and educational attainment were associated with risks of bipolar disorder. These findings suggest these disorders have disorder-specific genetic factors related to clinical phenotypes.
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收藏
页数：4
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