Nuclear imaging for cardiac amyloidosis

被引:13
|
作者
Noordzij, Walter [1 ]
Glaudemans, Andor W. J. M. [1 ]
Longhi, Simone [2 ,3 ]
Slart, Riemer H. J. A. [1 ]
Lorenzini, Massimiliano [2 ,3 ]
Hazenberg, Bouke P. C. [4 ]
Rapezzi, Claudio [2 ,3 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9700 RB Groningen, Netherlands
[2] Univ Bologna, Dept Cardiol, Bologna, Italy
[3] Malpighi Bologna Hosp, Bologna, Italy
[4] Univ Groningen, Univ Med Ctr Groningen, Rheumatol & Clin Immunol, NL-9700 RB Groningen, Netherlands
关键词
Amyloidosis; Nuclear medicine; PET; MIBG; Bone scintigraphy; MYOCARDIAL SYMPATHETIC INNERVATION; POSITRON-EMISSION-TOMOGRAPHY; TC-99M-DPD SCINTIGRAPHY; SYSTEMIC AMYLOIDOSIS; AL AMYLOIDOSIS; LIVER-TRANSPLANTATION; ACID SCINTIGRAPHY; BONE-SCINTIGRAPHY; VIABLE MYOCARDIUM; POLYNEUROPATHY;
D O I
10.1007/s10741-014-9463-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Histological analysis of endomyocardial tissue is still the gold standard for the diagnosis of cardiac amyloidosis, but has its limitations. Accordingly, there is a need for non-invasive modalities to diagnose cardiac amyloidosis. Echocardiography and ultrasound and magnetic resonance imaging can show characteristics which may not be very specific for cardiac amyloid. Nuclear medicine has gained a precise role in this context: several imaging modalities have become available for the diagnosis and prognostic stratification of cardiac amyloidosis during the last two decades. The different classes of radiopharmaceuticals have the potential to bind different constituents of the amyloidotic infiltrates, with some relevant differences among the various aetiologic types of amyloidosis and the different organs and tissues involved. This review focuses on the background of the commonly used modalities, their present clinical applications, and future clinical perspectives in imaging patients with (suspected) cardiac amyloidosis. The main focus is on conventional nuclear medicine (bone scintigraphy, cardiac sympathetic innervation) and positron emission tomography.
引用
收藏
页码:145 / 154
页数:10
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