Association between serum C-peptide levels and chronic microvascular complications in Korean type 2 diabetic patients

被引:65
|
作者
Kim, Bo-Yeon [1 ]
Jung, Chan-Hee [1 ]
Mok, Ji-Oh [1 ]
Kang, Sung-Koo [1 ]
Kim, Chul-Hee [1 ]
机构
[1] Soonchunhyang Univ, Coll Med, Bucheon Hosp, Div Endocrinol & Metab,Dept Internal Med, Puchon 420767, South Korea
关键词
C-peptide; Type 2 diabetes mellitus; Microvascular complications; Macrovascular complications; BETA-CELL FUNCTION; CORONARY-HEART-DISEASE; NITRIC-OXIDE; BLOOD-FLOW; METABOLIC CONTROL; RENAL-FUNCTION; ECG FINDINGS; MELLITUS; NEUROPATHY; INSULIN;
D O I
10.1007/s00592-010-0249-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study evaluated the association between serum C-peptide levels and chronic vascular complications in Korean patients with type 2 diabetes. Data for 1,410 patients with type 2 diabetes were evaluated cross-sectionally. Fasting and postprandial 2-hour serum C-peptide levels were analyzed with respect to diabetic micro- and macrovascular complications. In the group of patients with lower fasting serum C-peptide quartile, the prevalences of diabetic retinopathy and neuropathy were significantly higher (P = 0.035, P < 0.001, respectively). In the group of patients with lower delta C-peptide (postprandial - fasting C-peptide) quartile, the prevalences of diabetic retinopathy, nephropathy, and neuropathy were significantly higher (P < 0.001 for all). Low delta C-peptide quartile was also associated with increased severity of retinopathy and nephropathy. The age- and sex-adjusted odds ratios (ORs) for retinopathy, neuropathy, and nephropathy in the lowest versus the highest delta C-peptide quartile were 6.45 (95% confidence interval 3.41-12.22), 3.01 (2.16-4.19), and 2.65 (1.71-4.12), respectively. After further adjustment for the duration of diabetes, type of antidiabetic therapy, mean hemoglobin A1c, body mass index, and blood pressure, the ORs were reduced to 2.83 (1.32-6.08), 1.68 (1.12-2.53), and 1.61 (1.05-2.47), respectively, but remained significant. No significant difference was observed in the prevalence of macrovascular complications with respect to fasting or delta C-peptide quartiles. These results suggest that low C-peptide level is associated with diabetic microvascular, but not macrovascular complications in patients with type 2 diabetes mellitus.
引用
收藏
页码:9 / 15
页数:7
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