Microwave-assisted traceless synthesis of thiohydantoin

被引：51
|
作者：
Lin, MJ [1 ]
Sun, CM [1 ]
机构：
[1] Natl Dong Hwa Univ, Dept Chem, Hualien 974, Taiwan
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 48期
关键词：
D O I：
10.1016/j.tetlet.2003.09.156
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient, microwave-assisted method for the liquid-phase combinatorial synthesis of 3,5-disubstituted-thiohydantoin has been developed. Fmoc-protected amino acids were coupled with HO-PEG-OH and after deprotection, reacted with various isothiocyanates in microwave cavity. The PEG bound thiourea compounds underwent base mediated cyclization/cleavage step by microwave flash heating. The desired products were then liberated from the soluble matrix in good yield and purity under microwave exposure. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8739 / 8742
页数：4
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