Modification of host cell apoptosis by viral and bacterial pathogens

被引：24
|
作者：
Müller, A [1 ]
Rudel, T [1 ]
机构：
[1] Max Planck Inst Infekt Biol, Mol Biol Abt, D-10117 Berlin, Germany
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2001年 / 291卷 / 03期
关键词：
death receptor; mitochondria; caspase; v-FLIP; v-IAP; Bcl-2;
D O I：
10.1078/1438-4221-00125
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bacterial and viral pathogens have evolved sophisticated strategies to manipulate the host cell's life span to their own advantage. This is achieved by modifications of the intrinsic apoptosis program at several checkpoints: kinases, caspases and mitochondria. The goal of this review is to give an overview over the molecular mechanisms involved.
引用
收藏
页码：197 / 207
页数：11
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