A Case of Pyoderma Gangrenosum in a Patient with Rheumatoid Arthritis Treated with Abatacept

被引：5
|
作者：
Akahoshi-Ikeda, Maki [1 ]
Yoshizawa, Seiji [2 ]
Motoshita, Junichi [3 ]
Fume, Masutaka [4 ]
Takeuchi, Satoshi [1 ,4 ]
机构：
[1] Hamanomachi Hosp, Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Dermatol, Chuo Ku, Nagahama 3-3-1, Fukuoka 8108539, Japan
[2] Hamanomachi Hosp, Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Rheumatol, Chuo Ku, Nagahama 3-3-1, Fukuoka 8108539, Japan
[3] Hamanomachi Hosp, Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Pathol, Chuo Ku, Nagahama 3-3-1, Fukuoka 8108539, Japan
[4] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka, Japan
来源：
ACTA DERMATO-VENEREOLOGICA | 2016年 / 96卷 / 06期
关键词：
THERAPY; INFLAMMATION; INFLIXIMAB;
D O I：
10.2340/00015555-2380
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis induced by trauma or infection, which frequently appears on the lower legs. Various autoimmune diseases and systemic tumour necrosis factor (TNF)-α-blocking treatment cause PG, suggesting that T-cell-mediated reactions are involved in the aetiology. We report here for the first time a case of PG occurring during treatment with abatacept, a T-cell co-stimulation blocker. In addition, we discuss a possible underlying disease mechanism. © 2016 The Authors.
引用
收藏
页码：822 / 823
页数：2
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