Cyclin E overexpression in transitional cell carcinoma of the bladder

被引：21
|
作者：
Makiyama, K
Masuda, M
Takano, Y
Iki, M
Asakura, T
Suwa, Y
Noguchi, S
Hosaka, M
机构：
[1] Yokohama City Univ, Sch Med, Dept Urol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan
[2] Toyama Med & Pharmaceut Univ, Sch Med, Dept Pathol 1, Toyama 9300194, Japan
[3] Kinki Univ, Sch Med, Dept Publ Hlth, Osakasayama, Osaka 5898511, Japan
来源：
CANCER LETTERS | 2000年 / 151卷 / 02期
关键词：
cyclin E; p27(kip1); proliferative activity; immunohistochemistry; bladder neoplasms; transitional cell carcinoma;
D O I：
10.1016/S0304-3835(99)00421-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We attempted to clarify the relationship between cyclin E to p27(Kip1), Ki-67 and clinicopathologic features in transitional cell bladder carcinoma. Immunohistochemical staining of archival tissue specimens of transitional cell bladder carcinoma obtained from 94 patients was performed by the labeled streptavidin-biotin-peroxidase method. Overexpression of cyclin E protein was observed in 38 of the 94 (40.4%) specimens, and was positively correlated with histological grade, Ki-67 LI and p27(Kip1) labeling index (LI). These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27(Kip1) for the regulation of cell cycle progression in transitional cell bladder carcinoma. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：193 / 198
页数：6
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