An adeno-associated virus vector penetrates the blood-brain barrier in non-human primates

被引：0
|
作者：
Bei, Fengfeng [1 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
NATURE BIOMEDICAL ENGINEERING | 2022年 / 6卷 / 11期
关键词：
D O I：
10.1038/s41551-022-00939-6
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
standfirst Developing gene therapy for use in the central nervous system has been hampered by the lack of an efficient vector for gene delivery. We report an adeno-associated virus vector with an enhanced ability to cross the blood-brain barrier in both rodents and non-human primates, and use it to develop systemic anti-tumour gene therapies for glioblastoma.
引用
收藏
页码：1201 / 1202
页数：2
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