Allergen-Specific Immunotherapy for Respiratory Allergy in Children: Unmet Needs and Future Goals

被引：8

作者：

Comberiati, Pasquale ^{[1
]}

Marseglia, Gian Luigi ^{[2
]}

Barberi, Salvatore ^{[3
]}

Passalacqua, Giovanni ^{[4
]}

Peroni, Diego G. ^{[5
]}

机构：

[1] Univ Verona, Pediat Clin, Dept Surg Sci Dent Gynecol & Pediat, Verona, Italy

[2] Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia, Italy

[3] Fatebenefratelli Hosp, Dept Pediat, Milan, Italy

[4] Univ Genoa, IRCCS San Martino IST, Allergy & Resp Dis, Genoa, Italy

[5] Univ Pisa, Sect Pediat, Dept Clin & Expt Med, Pisa, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2017年 / 5卷 / 04期

关键词：

Allergy; Allergen-specific immunotherapy; Asthma; Allergic rhinitis; Children; Sublingual immunotherapy; Subcutaneous immunotherapy; RANDOMIZED CONTROLLED-TRIAL; SUBLINGUAL IMMUNOTHERAPY; INTERNATIONAL CONSENSUS; GRASS ALLERGY; EFFICACY; TABLETS; ASTHMA; SAFETY; AMERICAN; ADULTS;

D O I：

10.1016/j.jaip.2017.01.024

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergen-specific immunotherapy for the treatment of respiratory allergy is currently supported, at least for selected products, by evidence of efficacy and effectiveness in the pediatric age. However, unmet needs remain in terms of administration regimens, duration of treatment, biomarkers, and preventive effects. These knowledge gaps need to be urgently addressed to provide pediatricians and pediatric allergists with more definite recommendations for the use of this treatment in children. This article critically appraises the most relevant debated issues on allergen-specific immunotherapy in children, focusing on allergen standardization procedures, heterogeneity of clinical studies, and regulatory and pharmacoeconomic aspects. (C) 2017 American Academy of Allergy, Asthma & Immunology.

引用

页码：946 / 950

页数：5

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