Effects of Antidiabetic Drugs on Gut Microbiota Composition

被引:108
|
作者
Montandon, Sophie A. [1 ]
Jornayvaz, Francois R. [1 ]
机构
[1] Geneva Univ Hosp, Serv Endocrinol Diabet Hypertens & Nutr, Rue Gabrielle Perret Gentil 4, CH-1205 Geneva, Switzerland
关键词
gut microbiota; type; 2; diabetes; antidiabetic drugs; metformin; incretins; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; BILE-ACIDS; METFORMIN; DIET; GLUCAGON; METABOLISM; ACARBOSE; ALTERS; IMPACT;
D O I
10.3390/genes8100250
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Gut microbiota forms a catalog of about 1000 bacterial species; which mainly belong to the Firmicutes and Bacteroidetes phyla. Microbial genes are essential for key metabolic processes; such as the biosynthesis of short-chain fatty acids (SCFA); amino acids; bile acids or vitamins. It is becoming clear that gut microbiota is playing a prevalent role in pathologies such as metabolic syndrome; type 2 diabetes (T2D); inflammatory and bowel diseases. Obesity and related diseases; notably type 2 diabetes, induce gut dysbiosis. In this review; we aim to cover the current knowledge about the effects of antidiabetic drugs on gut microbiota diversity and composition as well as the potential beneficial effects mediated by specific taxa. Metformin is the first-line treatment against T2D. In addition to its glucose-lowering and insulin sensitizing effects, metformin promotes SCFA-producing and mucin-degrading bacteria. Other antidiabetic drugs discussed in this review show positive effects on dysbiosis; but without any consensus specifically regarding the Firmicutes to Bacteroidetes ratio. Thus, beneficial effects might be mediated by specific taxa.
引用
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页数:12
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