Isobolographic analysis of interaction between vigabatrin and baclofen in the formalin test in mice

被引：0
|
作者：
Czuczwar, M
Kis, J
Potasinski, A
Turski, WA
Przesmycki, K
机构：
[1] Med Univ Lublin, Dept Anesthesiol & Intens Therapy 2, PL-20081 Lublin, Poland
[2] Med Univ Lublin, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland
[3] Inst Agr Med, Dept Clin Toxicol, PL-20950 Lublin, Poland
来源：
POLISH JOURNAL OF PHARMACOLOGY | 2001年 / 53卷 / 05期
关键词：
vigabatrin; baclofen; nociception; formalin test;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Vigabatrin and baclofen given together, at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolo-graphic analysis revealed a significant synergy between both drugs in both phases of the formalin test.
引用
收藏
页码：527 / 530
页数：4
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