Transition-Metal-Free Cascade Approach for the Synthesis of Functionalized Biaryls by SNAr of Arylhydroxylamines with Arylsulfonium Salts

被引：1
|
作者：
Xu, Gaofei [1 ]
Han, Zongtao [2 ]
Guo, Lirong [1 ]
Lu, Haifeng [1 ]
Gao, Hongyin [1 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China
[2] Shandong Weifang Rainbow Chem Co Ltd, Weifang 262737, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 15期
基金：
中国国家自然科学基金;
关键词：
ARYL BOND FORMATION; COUPLING REACTIONS; ALDOL ADDITIONS; ARYLATION; DIARYLIODONIUM; CONSTRUCTION; SULFIDES;
D O I：
10.1021/acs.joc.2c00990
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a transition-metal-free protocol for the synthesis of functionalized biaryls through nucleophilic aromatic substitution (SNAr) of arylhydroxylamines to arylsulfonium salts. With this protocol, structurally diverse functionalized biaryls were obtained smoothly in moderate to good yields. Merits of this transformation include mild reaction conditions, broad substrate scope, great functional group tolerance, feasibility of a one-pot procedure, and ease of handing and scale-up.
引用
收藏
页码：10449 / 10453
页数：5
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