G protein-coupled receptor kinase 2 (GRK2):: mechanisms of regulation and physiological functions

被引：65
|
作者：
Aragay, AM [1 ]
Ruiz-Gómez, A [1 ]
Penela, P [1 ]
Sarnago, S [1 ]
Elorza, A [1 ]
Jiménez-Sainz, MC [1 ]
Mayor, F [1 ]
机构：
[1] Univ Autonoma Madrid, Dept Biol Mol, Ctr Biol Mol Severo Ochoa, CSIC, E-28049 Madrid, Spain
来源：
FEBS LETTERS | 1998年 / 430卷 / 1-2期
关键词：
G protein-coupled receptor kinase; desensitization; cardiovascular; chemokine receptor;
D O I：
10.1016/S0014-5793(98)00495-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization, Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：37 / 40
页数：4
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