Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity

被引：36
|
作者：
Salah, SM [1 ]
Jäger, AK [1 ]
机构：
[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 99卷 / 01期
关键词：
Artemisia herba-alba; cirsilineol; GABA(A)-benzodiazepine receptor; hispidulin;
D O I：
10.1016/j.jep.2005.01.031
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
An ethyl acetate extract of Artemisia herba-alba was partitioned by HPLC in 10 fractions that were tested in the [H-3]-flumazenil radioligand assay, for affinity to the GABA(A)-benzodiazepine receptor. Two fractions showed activity from which hispidulin and cirsilineol were isolated. The structures were confirmed by H-1 NMR. The IC50 values were 8 mu M for hispidulin and 100 mu M for cirsilineol. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：145 / 146
页数：2
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