Effects of fermented milk containing herb extract from Acanthopanax divaricatus var. albeofructus and Codonopsis lanceolata on the immune status of mouse

We have investigated the immunomodulatory activity of water extracts of Acanthopanax divaricatus var. alveofructus ill male ICP, mice. Mice were administrated with fermented milk containing freeze-dried extract 3 rng/Kg (A), 9 mg/Kg (B), 27 mg/Kg (C) per body weight with A. divaricatus var. alveofructus (loots : leaves : stein) : Codonopsis lanceolata = (5 : 2 : 1.5) : 1.5 for 7 and 10 weeks, respectively. Body weight, relative organ weight, cellularity of lymphoid organs, plaque-forming cell (PFC) assay, agglutination (AGG) test and lymphoproliferation were examined in various groups of animals. Any significant differences of body weight gain were not recorded in the tested ICR mice. There was significant different (p<0.05) in the spleen index in B group Of 10 weeks and C group of 7 weeks fed mouse. The thymus gain weight was increased during administration of the extract, but there was no significant increase on other organs gain. Humoral immunity as mesured by PFC showed more decreased PFC level in 10 weeks than ill 7 weeks. In the HT, A. divaricatus var. albeoficatus extract also showed a significant increase (p<0.05) in C group of 10 weeks. Administration of extracts from A. divaricatus var. albeofructus increased significantly in the production of IgG antibodies on the mice immunized with SRBC in B group of 7 and 10 weeks (p<0.05).