A limited sampling strategy for estimation of the area under the curve (0 to 8 hours) of mycophenolic acid administered three times daily to liver transplant recipients

被引:3
|
作者
Marcos, Bernardino [1 ]
Bouzas, Lorena [1 ]
Tutor, J. Carlos [1 ]
机构
[1] Hosp Clin Univ, Cent Lab, Unidad Monitorizac Farmacos, IDIS, Santiago De Compostela 15706, Spain
关键词
MOFETIL; PHARMACOKINETICS; SAFETY;
D O I
10.3109/03009734.2010.523801
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. Gastrointestinal side-effects caused by mycophenolic acid (MPA) are frequent in liver transplant recipients, and in these cases a switch from two to three daily doses is usually recommended. However, a limited sampling strategy for the estimation of MPA area under the curve from 0 to 8 hours (AUC((0--8h))) has not been made. Design and methods. In 22 liver transplant patients who were administered MPA three times daily, the trapezoidal extrapolated MPA AUC((0--8h)) values using a sampling time from 0 to 2 hours were calculated. Results. A tentative therapeutic range for MPA AUC((0--8h)) of about 20--40 mu mu g.h/mL is proposed, and in the 13 patients with supratherapeutic values the total leukocyte blood count was significantly lower than in the 9 patients with AUC((0--8h)) < a parts per thousand currency sign 40 mu mu g.h/mL (P < 0.001). Significant negative correlations were found between the total leukocyte blood count and the MPA trough levels (r == --0.458; P < 0.05), AUC((0--8h)) (r == --0.479; P < 0.05), and AUC((0--2h)) (r == --0.437; P < 0.05). A significant correlation was found between the trapezoidal extrapolated AUC((0--8h)) and trapezoidal AUC((0--2h)) results (r == 0.850; P < 0.001). Conclusions. The trapezoidal extrapolated AUC((0--8h)), and possibly trapezoidal AUC((0--2h)), may be useful for routine therapeutic MPA monitoring in liver transplant recipients in which the dosing frequency is increased from twice to three times a day.
引用
收藏
页码:47 / 51
页数:5
相关论文
共 50 条
  • [1] Pharmacokinetics of free mycophenolic acid and limited sampling strategy for the estimation of area under the curve in liver transplant patients
    Gu, Zhidong
    Chen, Bing
    Song, Yanyan
    Shen, Baiyong
    Zhu, Zhecheng
    Zhang, Weixia
    Xie, Junjie
    Deng, Xiaxing
    Peng, Chenghong
    Fan, Qishi
    Chen, Hao
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 47 (04) : 636 - 641
  • [2] Limited sampling strategy for the estimation of mycophenolic acid area under the curve in Tunisian renal transplant patients
    Gaies, Emna
    Ben Sassi, Mouna
    El Jebari, Hanene
    Jebabli, Nadia
    Charfi, Rim
    Chokri, Ichraf
    Salouage, Issam
    Klouz, Anis
    Trabelsi, Sameh
    [J]. NEPHROLOGIE & THERAPEUTIQUE, 2017, 13 (06): : 460 - 462
  • [3] Mycophenolic Acid Area under the Curve Monitoring via Limited Sampling Strategy in Pediatric Heart Transplant Recipients
    Crow, S. A.
    Dahl, S. H.
    Johnson, J. N.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2019, 38 (04): : S36 - S36
  • [4] Limited sampling strategy for mycophenolic acid area under the curve
    Filler, G
    Mai, I
    [J]. THERAPEUTIC DRUG MONITORING, 2000, 22 (02) : 169 - 173
  • [5] Pharmacokinetics of mycophenolic acid and determination of area under the curve by abbreviated sampling strategy in Chinese liver transplant recipients
    Chen, Hao
    Peng, Chenghong
    Yu, Zhicheng
    Shen, Baiyong
    Deng, Xiaxing
    Qiu, Weihua
    Fei, Yue
    Shen, Chuan
    Zhou, Guangwen
    Yang, Weiping
    Li, Hongwei
    [J]. CLINICAL PHARMACOKINETICS, 2007, 46 (02) : 175 - 185
  • [6] Pharmacokinetics of Mycophenolic Acid and Determination of Area Under the Curve by Abbreviated Sampling Strategy in Chinese Liver Transplant Recipients
    Hao Chen
    Chenghong Peng
    Zhicheng Yu
    Baiyong Shen
    Xiaxing Deng
    Weihua Qiu
    Yue Fei
    Chuan Shen
    Guangwen Zhou
    Weiping Yang
    Hongwei Li
    [J]. Clinical Pharmacokinetics, 2007, 46 : 175 - 185
  • [7] Mycophenolic Acid Area under the Curve Monitoring via limited Sampling Strategy in Pediatric Heart Transplant Recipients.
    Crow, S.
    Dahl, S. H.
    Johnson, J. N.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2019, 19 : 779 - 779
  • [8] Limited sampling strategy for the determination of mycophenolic acid area under the curve in pediatric kidney recipients
    Schütz, E
    Armstrong, VW
    Shipkova, M
    Weber, L
    Niedmann, PD
    Lammersdorf, T
    Wiesel, M
    Mandelbaum, A
    Zimmerhackl, LB
    Mehls, O
    Tönshoff, B
    Oellerich, M
    [J]. TRANSPLANTATION PROCEEDINGS, 1998, 30 (04) : 1182 - 1184
  • [9] Limited sampling strategy for simultaneous estimation of the area under the concentration-time curve of tacrolimus and mycophenolic acid in adult renal transplant recipients
    Miura, Masatomo
    Satoh, Shigeru
    Niioka, Takenori
    Kagaya, Hideaki
    Saito, Mitsuru
    Hayakari, Makoto
    Habuchi, Tomonori
    Suzuki, Toshio
    [J]. THERAPEUTIC DRUG MONITORING, 2008, 30 (01) : 52 - 59
  • [10] Performance of limited sampling strategies for predicting mycophenolic acid area under the curve in thoracic transplant recipients
    Ting, Lillian S. L.
    Partovi, Nilufar
    Levy, Robert D.
    Ignaszewski, Andrew P.
    Ensom, Mary H. H.
    [J]. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2008, 27 (03): : 325 - 328