Stem Cell-based Therapies for Bone Repair

被引：17
|
作者：
Milner, Peter I. [1 ]
Clegg, Peter D. [1 ]
Stewart, Matthew C. [2 ]
机构：
[1] Univ Liverpool, Dept Musculoskeletal Biol, Neston CH64 7TE, Cheshire, England
[2] Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61802 USA
来源：
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE | 2011年 / 27卷 / 02期
关键词：
Stem cell; Bone repair; Osteogenesis; Horse; ENDOTHELIAL PROGENITOR CELLS; AUTOGENOUS CANCELLOUS BONE; STROMAL CELLS; OSTEOGENIC DIFFERENTIATION; OSTEOBLAST DIFFERENTIATION; MORPHOGENETIC PROTEINS; TRICALCIUM PHOSPHATE; ADIPOSE-TISSUE; GENE-THERAPY; MARROW;
D O I：
10.1016/j.cveq.2011.05.002
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This article provides an overview of the cellular and molecular events involved in bone repair and the current approaches to using stem cells as an adjunct to this process. The article emphasizes the key role of osteoprogenitor cells in the formation of bone and where the clinical applications of current research may lend themselves to large animal orthopaedics. The processes involved in osteogenic differentiation are presented and strategies for bone formation, including induction by osteogenic factors, bio-scaffolds, and gene therapy, are reviewed.
引用
收藏
页码：299 / +
页数：17
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