Organisation of bone morphogenetic proteins in renal development

被引：13
|
作者：
Martinez, G
Bertram, JF [1 ]
机构：
[1] Monash Univ, Dept Anat & Cell Biol, Clayton, Vic 3800, Australia
[2] Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia
来源：
NEPHRON EXPERIMENTAL NEPHROLOGY | 2003年 / 93卷 / 01期
关键词：
D O I：
10.1159/000066649
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Bone morphogenetic proteins (BMPs) comprise the largest subfamily of the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Evidence for the involvement of BMPs in metanephric development emerged recently when renal phenotypes were observed in BMP7 null mutant mice. Since then, several other BMPs, BMP receptor serine/threonine kinases and BMP signal transduction molecules (Smads) have been implicated in mammalian metanephric development. It appears that particular BMPs have pivotal roles in specific aspects of metanephric development. Current knowledge and evidence of specific roles of particular BMPs are presented in this review. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码：E18 / E22
页数：5
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