Molybdenum supply of very low-birth-weight premature infants during the first months of life

被引:2
|
作者
Sievers, E [1 ]
Schleyerbach, U
Arpe, T
Garbe-Schönberg, D
Schaub, J
机构
[1] Univ Kiel, Dept Pediat, D-2300 Kiel, Germany
[2] Univ Kiel, Inst Geosci, Kiel, Germany
关键词
Mo; premature infants; trace elements; formula; nutrition;
D O I
10.1385/BTER:80:2:97
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This explorative study was performed to assess basic data on the Mo metabolism of premature infants. Premature (n = 18, gestational age less than or equal to 32 wk, birth weight less than or equal to 1500 g) and healthy formula-fed term infants (n = 14) were nourished and corrected for gestational age, identically. Plasma was collected at 3, 16, and 52 wk and 72 h balances were performed at 3 wk of age. In the premature infants, these investigations were preceded by two balance studies and an initial plasma collection. Increased Mo intake and low relative urinary excretion resulted in a retention of 4.4 (0.99-7.77) mug Mo/kg initially in premature infants (median, range). Parallel plasma concentrations were 5.5 (2.5-7.3) mug Mo/L,, declining to 2.36 (0.73-3.87) mug Mo/L at 4 wk. Term infants rendered 1.49 (0.29-1.7) mug Mo/L (p < 0.05), with no significant differences later. It was concluded that the supplementation of formulas for premature infants with Mo should be recinded until there is evidence for its necessity.
引用
收藏
页码:97 / 106
页数:10
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