Genetics Meets Environment: Evaluating Gene-Environment Interactions in Neurologic Diseases

被引：8
|
作者：
Marras, Connie [1 ]
Goldman, Samuel M. [2 ]
机构：
[1] Univ Toronto, Toronto Western Hosp, Movement Disorders Ctr, Toronto, ON M5T 2S8, Canada
[2] Parkinsons Inst, Sunnyvale, CA USA
来源：
SEMINARS IN NEUROLOGY | 2011年 / 31卷 / 05期
基金：
加拿大健康研究院;
关键词：
Genetics; environment; gene-environment interaction; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; EPIGENETICS; ASSOCIATION; DESIGNS; RISK;
D O I：
10.1055/s-0031-1299793
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The vast majority of disease is due to complex relationships between genetic and environmental factors. Single genetic or environmental causes are rare. Unfortunately, this presents major challenges for assessing disease risk in individuals. Further complicating the situation is the fact that there are many ways in which genetic and environmental determinants can combine to cause disease. This review explores the concepts of gene-environment interaction to provide a basic understanding of the principles of interactions and approaches to studying them. Collaborations between genetics and environmental experts will be crucial to understand the complex relationships.
引用
收藏
页码：553 / 561
页数：9
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