Solid Phases in the System L-Valine L-Isoleucine

被引：15

作者：

Isakov, Anton I. ^{[1
]}

Kotelnikova, Elena N. ^{[1
]}

Muenzberg, Stephan ^{[2
]}

Bocharov, Sergey N. ^{[1
]}

Lorenz, Heike ^{[2
]}

机构：

[1] St Petersburg State Univ, Dept Crystallog, St Petersburg 199155, Russia

[2] Max Planck Inst Dynam Complex Tech Syst, D-39106 Magdeburg, Germany

来源：

CRYSTAL GROWTH & DESIGN | 2016年 / 16卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

PLUS WATER-SYSTEM; CRYSTAL-STRUCTURE; ANOMALOUS RACEMATE; LIQUID EQUILIBRIA; MALIC-ACID; CRYSTALLIZATION; SOLUBILITY; ENANTIOMERS; COMPOUND; PURITY;

D O I：

10.1021/acs.cgd.5b01766

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two model compounds-valine C5H11NO2- (L-Val) and isoleucine C6H13NO2 (L-Ile)-were chosen to study isomorphism of the compounds formed by enantiomeric molecules having similar Shapes, but differing in the number of chiral centers. The X-ray powder diffraction method was applied to investigate samples with various ratios of valine and isoleucine crystallized from aqueous solutions by cooling and isothermal methods. Limited solid state miscibility between valine and isoleucine was established. A non-equimolar discrete compound with the molecular ratio Val:Ile = 2:1 (V2I) has been discovered, and its crystal structure was determined. Accordingly, the corresponding regions of solid solutions and two-phase areas in-between were distinguished. Solubility data in water support the phase behavior in the system.

引用

页码：2653 / 2661

页数：9

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