Citrullin-containing peptides as B-cell epitopes

被引：0
|
作者：
Sarmay, G. [1 ]
Szarka, E. [1 ]
Huber, K. [1 ]
Pozsgay, J. [1 ]
Szili, D. [1 ]
Babos, F. [2 ]
Nagy, Gy [3 ]
Rojkovich, B. [3 ]
Magyar, A. [2 ]
Hudecz, F. [2 ]
机构：
[1] Eotvos Lorand Univ, Dept Immunol, Pazmany Peter Setany 1-C, H-1117 Budapest, Hungary
[2] Eotvos Lorand Univ, HAS ELTE, Res Grp Peptide Chem, H-1117 Budapest, Hungary
[3] Hosp Bros St John, Buda Hosp, H-1023 Budapest, Hungary
来源：
4TH EUROPEAN CONFERENCE ON CHEMISTRY FOR LIFE SCIENCES | 2011年
基金：
匈牙利科学研究基金会;
关键词：
RHEUMATOID-ARTHRITIS; ANTIBODIES; AUTOANTIBODIES; VIMENTIN; PROTEINS; IDENTIFICATION; COLLAGEN; SYNOVIUM;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease, characterized by inflammatory polyarthritis. Anti-citrullinated protein antibodies (ACPA) are sensitive and specific markers for diagnosis and prognosis of RA. Citrulline and arginine containing filaggrin, collagen and vimentin peptides were investigated. The citrullin containing peptides were specifically recognized by ACPAs of subgroups of RA patients. We identified a five-mer minimal epitope of a 19-mer filaggrin peptide that were recognized by RA sera with a sensitivity and specificity comparable with the currently used tests. B-cells from RA patients activated by TLR9 and BAFF produced antibodies specific for the 5-mer epitope of citrullinated filaggrin, while B-cells from healthy individuals did not.
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收藏
页码：95 / 103
页数：9
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