Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis

被引：15

作者：

Zabalza, Ana ^{[1
]}

Arrambide, Georgina ^{[1
]}

Tagliani, Paula ^{[1
]}

Cardenas-Robledo, Simon ^{[1
]}

Otero-Romero, Susana ^{[1
,2
]}

Esperalba, Juliana ^{[3
]}

Fernandez-Naval, Candela ^{[3
]}

Trocoli Campuzano, Jesus ^{[3
]}

Martinez Gallo, Monica ^{[4
,5
]}

Castillo, Mireia ^{[1
]}

Bonastre, Merce ^{[1
]}

Resina Salles, Mireia ^{[1
]}

Beltran, Jordina ^{[1
]}

Carbonell-Mirabent, Pere ^{[1
]}

Rodriguez-Barranco, Marta ^{[1
]}

Lopez-Maza, Samuel ^{[1
]}

Melgarejo Otalora, Pedro Jose ^{[6
]}

Ruiz-Ortiz, Mariano ^{[7
]}

Pappolla, Agustin ^{[1
]}

Rodriguez Acevedo, Breogan ^{[1
]}

Midaglia, Luciana ^{[1
]}

Vidal-Jordana, Angela ^{[1
]}

Cobo-Calvo, Alvaro ^{[1
]}

Tur, Carmen ^{[1
]}

Galan, Ingrid ^{[1
]}

Castillo, Joaquin ^{[1
]}

Rio, Jordi ^{[1
]}

Espejo, Carmen ^{[1
]}

Comabella, Manuel ^{[1
]}

Nos, Carlos ^{[1
]}

Sastre-Garriga, Jaume ^{[1
]}

Tintore, Mar ^{[1
]}

Montalban, Xavier ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Univ Vali dHebron, Vali dHebron Inst Recerca,Serv Neurol Neuroimmuno, Ctr Esclerosi Mdltiple Catalunya Cemcat,Dept Med, Barcelona, Spain

[2] Univ Autonoma Barcelona, Hosp Univ Vali dHebron, Vali dHebron Inst Recerca,Prevent Med & Epidemiol, Ctr Esclerosi Mdltiple Catalunya Cemcat,Dept Med, Barcelona, Spain

[3] Univ Autonoma Barcelona, Vali dHebron Univ Hosp, Microbiol Dept, Vali dHebron Barcelona Hosp Campus, Barcelona, Spain

[4] Hosp Univ Vali dHebron, Immunol Div, Barcelona, Spain

[5] Vali dHebron Res Inst VHIR, Diagnost Immunol Res Grp, Barcelona, Spain

[6] Hosp Gen Univ Gregorio Maranon, Dept Neurol, Madrid, Spain

[7] Hosp Univ 12 Octubre, Dept Neurol, Madrid, Spain

来源：

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2022年 / 9卷 / 02期

关键词：

D O I：

10.1212/NXI.0000000000001143

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Objectives Information about humoral and cellular responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antibody persistence in convalescent (COVID-19) patients with multiple sclerosis (PwMS) is scarce. The objectives of this study were to investigate factors influencing humoral and cellular responses to SARS-CoV-2 and its persistence in convalescent COVID-19 PwMS. Methods This is a retrospective study of confirmed COVID-19 convalescent PwMS identified between February 2020 and May 2021 by SARS-CoV-2 antibody testing. We examined relationships between demographics, MS characteristics, disease-modifying therapy (DMT), and humoral (immunoglobulin G against spike and nucleocapsid proteins) and cellular (interferon-gamma [IFN-gamma]) responses to SARS-CoV-2. Results A total of 121 (83.45%) of 145 PwMS were seropositive, and 25/42 (59.5%) presented a cellular response up to 13.1 months after COVID-19. Anti-CD20-treated patients had lower antibody titers than those under other DMTs (p < 0.001), but severe COVID-19 and a longer time from last infusion increased the likelihood of producing a humoral response. IFN-gamma levels did not differ among DMT. Five of 7 (71.4%) anti--CD20-treated seronegative patients had a cellular response. The humoral response persisted for more than 6 months in 41/56(81.13%) PwMS. In multivariate analysis, seropositivity decreased due to anti-CD20 therapy (OR 0.08 [95% CI 0.01-0.55]) and increased in males (OR 3.59 [1.02-12.68]), whereas the cellular response decreased in those with progressive disease (OR 0.04 [0.001-0.88]). No factors were associated with antibody persistence. Discussion Humoral and cellular responses to SARS-CoV-2 are present in COVID-19 convalescent PwMS up to 13.10 months after COVID-19. The humoral response decreases under anti-CD20 treatment, although the cellular response can be detected in anti-CD20-treated patients, even in the absence of antibodies.

引用

页数：13

共 50 条

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