Genetic studies of inflammatory bowel disease

Inflammatory bowel disease (IBD) arises in part from a genetic predisposition to develop the disease, through the inheritance of a number of contributory genetic polymorphisms. These variant forms of genes may be associated with an abnormal response to normal luminal bacteria, possibly in combination with an environmental or dietary stimulus, that in turn leads to an excessive immune response. Therefore, central to understanding the etiology of IBD is the identification of the key genetic defects that enhance susceptibility. Characterising the genetic basis for IBD will allow us to understand the pathogenesis of the disease, and provide better targets for future preventative treatments.