An open-label trial of escitalopram in children and adolescents with social anxiety disorder

被引:26
|
作者
Isolan, Luciano [1 ,2 ]
Pheula, Gabriel [1 ,2 ]
Salum, Giovanni Abrahao, Jr. [1 ,2 ]
Oswald, Sylvia [1 ,2 ]
Rohde, Luis Augusto [1 ,2 ]
Manfro, Gisele Gus [1 ,2 ]
机构
[1] Univ Fed Rio Grande do Sul, Postgrad Program Med Sci Psychiat, Porto Alegre, RS, Brazil
[2] Hosp Clin Porto Alegre, Anxiety Disorders Program, Porto Alegre, RS, Brazil
关键词
D O I
10.1089/cap.2007.0007
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Social anxiety disorder ( SAD) is a highly prevalent and disabling disorder in children and adolescents. This study was designed to evaluate the efficacy and safety of a highly potent and selective serotonin reuptake inhibitor, escitalopram, in the treatment of SAD in children and adolescents. Twenty outpatients with a primary diagnosis of SAD were treated in a 12-week open trial with escitalopram. The primary outcome variable was the change from baseline to end point in Clinical Global Impression-Improvement scale (CGI-I). Secondary efficacy measures included the CGI-Severity scale (CGI-S), the Social Phobia and Anxiety Inventory for Children (SPAI-C), the Screen for Child and Anxiety Related Emotional Disorders (SCARED)-Child and Parent version, and The Youth Quality of Life Instrument-Research Version (Y-QOL-R). On the CGI-I scale, 13 of 20 patients (65%) had a score <= 2, meaning response to treatment. All symptomatic and quality of life measures showed improvements from baseline to week 12, with large effect sizes ranging from 0.9 to 1.9 (all p = 0.001). Escitalopram was generally well-tolerated. These results suggest that escitalopram may be an effective and safe treatment for pediatric SAD. Future double-blind, placebo-controlled, randomized clinical trials are warranted.
引用
收藏
页码:751 / 759
页数:9
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