Long term outcome of antiviral therapy in patients with hepatitis B associated decompensated cirrhosis
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作者:
Ju, Young-Cheol
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Hanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South KoreaHanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
Ju, Young-Cheol
[1
]
Jun, Dae-Won
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Hanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
Hanyang Univ, Sch Med, Dept Internal Med, 222 Wangsimni Ro, Seoul 04763, South KoreaHanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
Jun, Dae-Won
[1
,2
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Choi, Jun
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Korea Univ, Dept Ind Management Engn, Seoul 02841, South KoreaHanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
Choi, Jun
[3
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Saeed, Waciar Khalid
[2
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Lee, Hyo-Young
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Hanyang Univ, Sch Med, Dept Internal Med, 222 Wangsimni Ro, Seoul 04763, South KoreaHanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
Lee, Hyo-Young
[2
]
Oh, Hyun-Woo
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Hanyang Univ, Sch Med, Dept Internal Med, 222 Wangsimni Ro, Seoul 04763, South KoreaHanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
Oh, Hyun-Woo
[2
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机构:
[1] Hanyang Univ, Grad Sch Biomed Sci & Engn, Dept Translat Med, Seoul 04763, South Korea
[2] Hanyang Univ, Sch Med, Dept Internal Med, 222 Wangsimni Ro, Seoul 04763, South Korea
[3] Korea Univ, Dept Ind Management Engn, Seoul 02841, South Korea
AIM To investigate survival rate and incidence of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis in the antiviral era. METHODS We used the Korean Health Insurance Review and Assessment. Korea's health insurance system is a public single-payer system. The study population consisted of 286871 patients who were prescribed hepatitis B antiviral therapy for the first time between 2007 and 2014 in accordance with the insurance guidelines. Overall, 48365 antiviral treatment-naive patients treated between 2008 and 2009 were included, and each had a follow-up period >= 5 years. Data were analyzed for the 1 st decompensated chronic hepatitis B (CHB) and treatment-naive patients (n = 7166). RESULTS The mean patient age was 43.5 years. The annual mortality rates were 2.4%-19.1%, and 5-year cumulative mortality rate was 32.6% in 1 st decompensated CHB treatment-naive subjects. But the annual mortality rates sharply decreased to 3.4% (2.4%-4.9%, 2-5 year) after one year of antiviral treatment. Incidence of HCC at first year was 14.3%, the annual incidence of HCC decreased to 2.5% (1.8%-3.7%, 2-5 year) after one year. 5-year cumulative incidence of HCC was 24.1%. Recurrence rate of decompensated event was 46.9% at first year, but the annual incidence of second decompensation events in decompensated CHB treatment-naive patients was 3.4% (2.1%-5.4%, 2-5 year) after one year antiviral treatment. 5-year cumulative recurrence rate of decompensated events was 60.6%. Meanwhile, 5-year cumulative mortality rate was 3.1%, and 5-year cumulative incidence of HCC was 11.5% in compensated CHB treatment-naive patients. CONCLUSION Long term outcome of decompensated cirrhosis treated with antiviral agent improved much, and incidence of hepatocellular carcinoma and mortality sharply decreased after one year treatment.
机构:
Casa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, ItalyCasa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, Italy
Iacobellis, Angelo
Perri, Francesco
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Casa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, ItalyCasa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, Italy
Perri, Francesco
Valvano, Maria Rosa
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Casa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, ItalyCasa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, Italy
Valvano, Maria Rosa
Caruso, Nazario
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Casa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, ItalyCasa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, Italy
Caruso, Nazario
Niro, Grazia Anna
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Casa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, ItalyCasa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, Italy
Niro, Grazia Anna
Andriulli, Angelo
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Casa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, ItalyCasa Sollievo della Sofferenza Hosp, Div Gastroenterol & Digest Endoscopy, IRCCS, I-71013 San Giovanni Rotondo, Italy
机构:
Nanjing Mil Command, Shanghai Liver Dis Res Ctr, Shanghai 200235, Peoples R ChinaNanjing Mil Command, Shanghai Liver Dis Res Ctr, Shanghai 200235, Peoples R China
Fu, Qingchun
Chen, Chengwei
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Nanjing Mil Command, Shanghai Liver Dis Res Ctr, Shanghai 200235, Peoples R ChinaNanjing Mil Command, Shanghai Liver Dis Res Ctr, Shanghai 200235, Peoples R China
机构:
Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R China
Chen Guang-cheng
Yu Tao
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Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R China
Yu Tao
Huang Kai-hong
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Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R China
Huang Kai-hong
Chen Qi-kui
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Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R ChinaSun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Gastroenterol, Guangzhou 510120, Guangdong, Peoples R China
机构:
Department of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen UniversityDepartment of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen University
CHEN Guang-cheng
YU Tao
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Department of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen UniversityDepartment of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen University
YU Tao
HUANG Kai-hong
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Department of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen UniversityDepartment of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen University
HUANG Kai-hong
CHEN Qi-kui
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Department of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen UniversityDepartment of Gastroenterology,the Sun Yat-sen Memorial Hospital,Sun Yat-sen University