Isoindolinone enantiomers having affinity for the dopamine D4 receptor

被引：209

作者：

Belliotti, TR ^{[1
]}

Brink, WA ^{[1
]}

Kesten, SR ^{[1
]}

Rubin, JR ^{[1
]}

Wustrow, DJ ^{[1
]}

Zoski, KT ^{[1
]}

Whetzel, SZ ^{[1
]}

Corbin, AE ^{[1
]}

Pugsley, TA ^{[1
]}

Heffner, TG ^{[1
]}

Wise, LD ^{[1
]}

机构：

[1] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(98)00252-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

PD 108635 (1) was identified as a potent dopamine D-4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D-4 affinity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1499 / 1502

页数：4

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