Idiotype vaccine strategies for treatment of follicular lymphoma

被引：2

作者：

Mahaseth, Hemchandra ^{[1
]}

Brody, Joshua D. ^{[2
]}

Sinha, Rajni ^{[1
]}

Shenoy, Pareen J. ^{[1
]}

Flowers, Christopher R. ^{[1
]}

机构：

[1] Emory Univ, Dept Hematol Oncol, Winship Canc Inst, Atlanta, GA 30322 USA

[2] Stanford Univ, Med Ctr, Dept Med, Div Oncol, Stanford, CA 94305 USA

来源：

FUTURE ONCOLOGY | 2011年 / 7卷 / 01期

关键词：

cancer vaccine; follicular lymphoma; idiotype vaccine; immunoglobulin idiotypes; immunotherapy; B-CELL LYMPHOMA; COLONY-STIMULATING FACTOR; NON-HODGKINS-LYMPHOMA; IMMUNE-RESPONSES; MITUMPROTIMUT-T; LOW-GRADE; ACTIVE IMMUNOTHERAPY; TREATMENT OPTIONS; CLINICAL BENEFIT; FREE SURVIVAL;

D O I：

10.2217/FON.10.159

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Follicular lymphoma is an indolent lymphoma associated with a relapsing course. Immunization with tumor B cell idiotype (Id; a unique variable region of surface B cell immunoglobulin) may induce humoral and cellular immune response against the tumor. Based on promising results from early phase clinical trials with Id vaccine, three Phase III trials were initiated, which, despite failing to meet their primary end points, still provided a glimmer of optimism. This article describes the clinical development of the Id vaccine against follicular lymphoma, outlines the outcomes of clinical trials and delineates the future prospects for the integration of the idiotype vaccine into follicular lymphoma treatment.

引用

页码：111 / 122

页数：12

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