Penetration of cefprozil to middle ear effusion in children with chronic otitis media with effusion

Background: Because of chronic otitis media with effusion (COME) demonstrates pathogenic bacteria, treatment with appropriate antibiotic is reasonable. Objective: We determined the penetration of cefprozil into the middle ear effusion (MEE) in children with COME. Materials and methods: 25 patients 2-13 years of age with COME were eligible for study. After the single dose of 15 mg/kg patients were assigned to have MEE, and serum samples were obtained during ventilation tube insertion at 0.5, 2, 3, 5, or 6 h after administration of the dose. The concentration of cefprozil was measured using validated high performance liquid chromatography method. Results: The mean concentrations of cefprozil in the MEE ranged from 0.4 to 4.4 mug/ml. The penetration into MEE was rapid and effective. Cefprozil in the MEE was maintained at a greater level than MIC 90 in S. pneumoniae for at least 6 h after administration of 15 mg/kg. Conclusion: cefprozil penetrated well into the MEE in children with COME. (C) 2003 Elsevier Ireland Ltd. All rights reserved.