Large-scale manufacture of peptide therapeutics by chemical synthesis

被引：453
|
作者：
Bray, BL [1 ]
机构：
[1] Trimeris Inc, Durham, NC 27707 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 07期
关键词：
D O I：
10.1038/nrd1133
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The large-scale commercial production of a 36-amino-acid peptide by chemical synthesis has been demonstrated in the development of enfuvirtide (T-20 or Fuzeon), a first-in-class membrane fusion inhibitor for the treatment of HIV. The rationale behind route selection and the scale-up of the process used to manufacture enfuvirtide are discussed.
引用
收藏
页码：587 / 593
页数：7
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