Efficacy of Anti-Interleukin-1 Receptor Antagonist Anakinra (Kineret®) in a Case of Refractory Sweet's Syndrome

被引：67
|
作者：
Kluger, Nicolas [1 ,2 ,3 ,4 ]
Gil-Bistes, Deborah [1 ]
Guillot, Bernard [1 ]
Bessis, Didier [1 ]
机构：
[1] Univ Montpellier 1, Serv Dermatol, Hop St Eloi, CHU Montpellier, Montpellier, France
[2] Univ Helsinki, Helsinki Univ Cent Hosp, Dept Dermatol, Inst Clin Med,Skin & Allergy Hosp, Helsinki, Finland
[3] Univ Helsinki, Helsinki Univ Cent Hosp, Dept Allergol, Inst Clin Med,Skin & Allergy Hosp, Helsinki, Finland
[4] Univ Helsinki, Helsinki Univ Cent Hosp, Dept Venereol, Inst Clin Med,Skin & Allergy Hosp, Helsinki, Finland
来源：
DERMATOLOGY | 2011年 / 222卷 / 02期
关键词：
Sweet's syndrome; Neutrophilic dermatosis; Anakinra; Interleukin-1 receptor antagonist; TUMOR-NECROSIS-FACTOR; ULCERATIVE-COLITIS; CROHNS-DISEASE; INTERLEUKIN-1; PATHOGENESIS; ETANERCEPT; ARTHRITIS; IL-1;
D O I：
10.1159/000326112
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Sweet's syndrome is a neutrophilic dermatosis characterized by fever, an elevated neutrophil count, and painful erythematous cutaneous lesions. Histopathological analysis reveals a neutrophilic dermal infiltrate. Systemic corticosteroid therapy remains the mainstay of treatment. We report the case of a 66-year-old male patient who had a 5-year history of Sweet's syndrome refractory to various conventional treatments. Anti-inter-leukin-1 receptor antagonist anakinra was initiated and this resulted in a dramatic clinical and biological improvement. Anakinra is a promising treatment for neutrophilic dermatoses and sheds light on the interleukin-1/inflammasome pathway as central in the physiopathology of neutrophilic dermatosis. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码：123 / 127
页数：5
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