Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis

被引：18
|
作者：
Pathak, AK
Pathak, V
Kulshrestha, M
Kinnaird, D
Suling, WJ
Gurcha, SS
Besra, GS
Reynolds, RC
机构：
[1] So Res Inst, Drug Discovery Div, Birmingham, AL 35255 USA
[2] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
来源：
TETRAHEDRON | 2003年 / 59卷 / 51期
关键词：
Mycobacterium tuberculosis; glycosyltransferase; arabinofuranose; inhibitors;
D O I：
10.1016/j.tet.2003.10.054
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10239 / 10248
页数：10
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