Pyrrole-Based Scaffolds for Turn Mimics

被引：25
|
作者：
Ko, Eunhwa [1 ]
Burgess, Kevin [1 ]
机构：
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 05期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
PROTEIN-PROTEIN INTERACTIONS; BETA-D-GLUCOSE; ALPHA-HELIX; AMINO-ACIDS; DESIGN; INHIBITORS; PEPTIDOMIMETICS; PROTEOMIMETICS; RECOGNITION; ANTAGONIST;
D O I：
10.1021/ol103022m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two amino acid derived synthons were combined to give homopropargylic amines 2. Platinum dichloride was used to cyclize these intermediates into pyrroles 3 which collapsed to the target secondary structure mimics 1 on treatment with base. Side chains of these compounds overlay with an idealized type 1 beta-turn and with an inverse gamma-turn.
引用
收藏
页码：980 / 983
页数：4
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