Formation of a physical stable delivery system by simply autoclaving nanostructured lipid carriers (NLC)

被引：14
|
作者：
Pardeike, Jana [1 ]
Weber, Sabrina [1 ]
Matsko, Nadejda [2 ,3 ]
Zimmer, Andreas [1 ]
机构：
[1] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmaceut Technol, A-8010 Graz, Austria
[2] Graz Univ Technol, Inst Electron Microscopy & Fine Struct Res, A-8010 Graz, Austria
[3] Graz Univ Technol, Ctr Electron Microscopy Graz FELMI ZFE, A-8010 Graz, Austria
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 439卷 / 1-2期
关键词：
Autoclaving; Cryo-TEM; Lamellar bilayer; Nanostructured lipid carriers; Poorly solubles; AQUEOUS MONOOLEIN/POLOXAMER DISPERSIONS; NANOPARTICLES SLN; DRUG-DELIVERY; CUBIC NANOPARTICLES; HEAT-TREATMENT; TRANSFORMATION; STERILIZATION; FORMULATION;
D O I：
10.1016/j.ijpharm.2012.09.018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A unique long term stable carrier system for poorly soluble drugs was obtained by simply autoclaving nanostructured lipid carriers (NLC). NLC composed of Precirol ATO, oleic acid, glycerol 85%, Eumulgin SML 20 and water as well as NLC loaded with the poorly soluble drug Itraconazole formed a special organized matrix containing lamellar bilayers similar to biological membranes after the sterilization process. The tendency to expel the poorly soluble drug from the matrix was thereby avoided. (C) 2012 Elsevier B. V. All rights reserved.
引用
收藏
页码：22 / 27
页数：6
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