Platelet/endothelial cell adhesion molecule-1 (PECAM-1) expression by human brain microvessel endothelial cells in primary culture

被引：18
|
作者：
Wong, D
DoroviniZis, K
机构：
[1] VANCOUVER GEN HOSP,DEPT PATHOL & LAB MED,SECT NEUROPATHOL,VANCOUVER,BC V5Z 1M9,CANADA
[2] UNIV BRITISH COLUMBIA,VANCOUVER,BC V5Z 1M9,CANADA
来源：
BRAIN RESEARCH | 1996年 / 731卷 / 1-2期
关键词：
brain endothelium; cell adhesion molecule; CD31; primary culture;
D O I：
10.1016/S0006-8993(96)00673-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
PECAM-1 expression was investigated in primary cultures of human brain microvessel endothelial cells (HBMEC). HBMEC constitutively express PECAM-1 along their apical cell surface, advancing processes and on the basal surface at points of contact with the extracellular matrix. Surface expression is not altered by cytokine or lipopolysaccharide treatment. This distribution may mediate cell-cell contact and migration during angiogenesis and HBMEC-leukocyte interactions in CNS inflammation.
引用
收藏
页码：217 / 220
页数：4
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