What's next for the synthetic lethality drug discovery engine?

被引:7
|
作者
Mullard, Asher
机构
关键词
D O I
10.1038/d41573-022-00107-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
As a surge of cancer drugs with new synthetic lethality targets enter the clinic, the opportunities and challenges of the underlying discovery strategies are coming into focus.
引用
收藏
页码:477 / 479
页数:3
相关论文
共 50 条
  • [1] What’s next for the synthetic lethality drug discovery engine?
    Asher Mullard
    [J]. Nature Reviews Drug Discovery, 2022, 21 : 477 - 479
  • [2] Synthetic lethality as an engine for cancer drug target discovery
    Alan Huang
    Levi A. Garraway
    Alan Ashworth
    Barbara Weber
    [J]. Nature Reviews Drug Discovery, 2020, 19 : 23 - 38
  • [3] Synthetic lethality as an engine for cancer drug target discovery
    Huang, Alan
    Garraway, Levi A.
    Ashworth, Alan
    Weber, Barbara
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2020, 19 (01) : 23 - 38
  • [4] What's next for chronobiology and drug discovery
    Chen, Zheng
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2017, 12 (12) : 1181 - 1185
  • [5] Kinase Drug Discovery - What's Next in the Field?
    Cohen, Philip
    Alessi, Dario R.
    [J]. ACS CHEMICAL BIOLOGY, 2013, 8 (01) : 96 - 104
  • [6] Synthetic lethality on drug discovery: an update on cancer therapy
    Yar, M. Shahar
    Haider, Kashif
    Gohel, Vivek
    Siddiqui, Nasir Ali
    Kamal, Ahmed
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2020, 15 (07) : 823 - 832
  • [7] Drug discovery and the genome: What next?
    Liszewski, K
    [J]. GENETIC ENGINEERING NEWS, 2002, 22 (19): : 16 - +
  • [8] Informatics and drug discovery - What is next
    Cohen, FE
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 394 - COMP
  • [9] A lethal combination for cancer cells: Synthetic lethality screenings for drug discovery
    Ferrari, Elisa
    Lucca, Chiara
    Foiani, Marco
    [J]. EUROPEAN JOURNAL OF CANCER, 2010, 46 (16) : 2889 - 2895
  • [10] Using synthetic lethality in Drosophila melanogaster for drug target discovery.
    Marek, LR
    Busygina, V
    Bale, AE
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (05) : 237 - 237