Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

被引：0
|
作者：
Hromas, R
Boswell, S
Shen, RN
Burgess, G
Davidson, A
Cornetta, K
Sutton, J
Robertson, K
机构：
[1] INDIANA UNIV, MED CTR, WALTHER ONCOL CTR, INDIANAPOLIS, IN 46202 USA
[2] INDIANA UNIV, MED CTR, DEPT RADIAT THERAPY, INDIANAPOLIS, IN 46202 USA
[3] INDIANA UNIV, MED CTR, WELLS CTR PEDIAT RES, INDIANAPOLIS, IN 46202 USA
来源：
LEUKEMIA | 1996年 / 10卷 / 06期
关键词：
transcription factors; oncogenesis; apoptosis; retroviral gene transfer;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3-dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.
引用
收藏
页码：1049 / 1050
页数：2
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