Neuron model-free control of drug infusion rate

This paper investigates the use of adaptive neuron model-free control techniques for automatic control of mean arterial pressure (MAP) through the intravenous infusion of sodium nitroprusside(SNP). Because the transfer function parameters are different for each patient and furthermore are variable with time, an adaptive algorithm is desirable for maintaining both stead-state and transient specifications. A new neuron model-free control method is proposed for blood pressure regulation in this paper. One of its outstanding advantages is that the neuron controller generates the control signal not based on plant model, but on learning of the inputs and outputs of the process. The computer simulations have shown that the incremental neuron model-free control procedures might be successfully applied the control of brood pressure despite the uncertainty in the delays, time constant and gains.