Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured human thyrocytes

被引：42
|
作者：
Kasai, K [1 ]
Banba, N [1 ]
Motohashi, S [1 ]
Hattori, Y [1 ]
Manaka, K [1 ]
Shimoda, SI [1 ]
机构：
[1] DOKKYO UNIV, SCH MED, CTR TISSUE CULTURE, MIBU, TOCHIGI 32102, JAPAN
来源：
FEBS LETTERS | 1996年 / 394卷 / 02期
关键词：
thyrocyte; monocyte chemoattractant protein-1; interleukin-1; tumor necrosis factor-alpha; interferon-gamma;
D O I：
10.1016/0014-5793(96)00935-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Monocytes as well as lymphocytes infiltrate in the stroma of thyroid tissue in autoimmune and destructive thyroiditis, Monocyte chemoattractant protein-1 (MCP-1) is a cytokine that attracts T-lymphocytes as well as monocytes, Using human thyrocytes in primary cultures, we show that expression of MCP-1 mRNA and protein is remarkably stimulated by both interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and also that interferon-gamma (IFN-gamma) by itself is a weak stimulant but has a synergistic activity with either IL-1 or TNF-alpha. The finding indicates that MCP-1 can be produced by thyrocytes themselves, suggesting a possible role of thyrocytes on accumulation of monocytes and T-lymphocytes to the tissue from the blood in autoimmune and destructive thyroiditis.
引用
收藏
页码：137 / 140
页数：4
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