Immunomodulation for maxillofacial reconstructive surgery

被引：17
|
作者：
Kim, Seong-Gon [1 ]
机构：
[1] Gangneung Wonju Natl Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Kangnung 25457, Jukhyun Gil, South Korea
来源：
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY | 2020年 / 42卷 / 01期
关键词：
Immunomodulation; Macrophage; Wound healing; 4-Hexylresorcinol; TITANIUM SURFACE-TOPOGRAPHY; MULTINUCLEATED GIANT-CELLS; TRANSFORMING-GROWTH-FACTOR; COATED DENTAL IMPLANTS; FOREIGN-BODY REACTION; BONE-FORMATION; MACROPHAGE ACTIVATION; CYTOKINE PRODUCTION; TGF-BETA; EXPRESSION;
D O I：
10.1186/s40902-020-00249-4
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Immunomodulation is a technique for the modulation of immune responses against graft material to improve surgical success rates. The main target cell for the immunomodulation is a macrophage because it is the reaction site of the graft and controls the healing process. Macrophages can be classified into M1 and M2 types. Most immunomodulation techniques focus on the rapid differentiation of M2-type macrophage. An M2 inducer, 4-hexylresorcinol, has been recently identified and is used for bone grafts and dental implant coatings.
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页数：9
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