Development of a standard method for in vitro evaluation of Triamcinolone and BMP-2 diffusion mechanism from thermosensitive and biocompatible composite hyaluronic acid-pluronic hydrogels

被引：8

作者：

Santovena, A. ^{[1
]}

Monzon, C. ^{[1
]}

Delgado, A. ^{[1
]}

Evora, C. ^{[1
]}

Llabres, M. ^{[1
]}

Farina, J. B. ^{[1
]}

机构：

[1] Univ La Laguna, Fac Farm, Dept Ingn Quim & Tecnol Farmaceut, Tenerife 38200, Spain

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2017年 / 42卷

关键词：

Pluronic F127 hydrogel; Hyaluronic acid-pluronic hydrogel; Gellan hydrogel; Triamcinolone acetonide; Bone morphogenetic protein-2; Diffusion mechanism; DRUG-DELIVERY; CONTROLLED-RELEASE; SOLUTE RELEASE; EQUATION; GELS;

D O I：

10.1016/j.jddst.2017.04.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this paper we describe a simple reproducible in vitro method to study the diffusion of two different drugs with varying physico-chemical properties from two thermosensitive biocompatible polymeric hydrogels. This system enabled characterization of the in vitro diffusion mechanism of triamcinolone and bone morphogenetic protein-2 from pluronic and from composite hyaluronic acid-pluronic hydrogels in gellan that simulates the in vivo environment. By this method we determined critical factors involved in the modulation of the drug diffusion from these controlled release devices, which allowed us to modulate the drug-release profile and simulate in vivo drug behavior. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：284 / 291

页数：8