Two Cases of Acute Macular Neuroretinopathy Associated with the Adenovirus-based COVID-19 Vaccine Vaxzevria (Astrazeneca)

被引:10
|
作者
Franchi, Alexander [1 ]
Rauchegger, Teresa [1 ]
Palme, Christoph [1 ]
Frede, Katharina [1 ]
Haas, Gertrud [1 ]
Blatsios, Georgios [1 ]
Kralinger, Martina [1 ]
Zehetner, Claus [1 ]
机构
[1] Med Univ Innsbruck, Dept Ophthalmol & Optometry, Anichstr 35, A-6020 Innsbruck, Austria
关键词
Acute macular neuroretinopathy; vaccination; SARS-CoV-2; COVID-19; vaxzevria;
D O I
10.1080/09273948.2022.2027463
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca). Methods: Spectral-domain optical coherence tomography and infrared imaging were used to confirm the diagnosis of AMN. Results: Both patients showed a parafoveal hyperreflective band in the outer nuclear layer, disruption of the ellipsoid and interdigitation zones of the photoreceptor layers, and correlating hyporeflective areas on the near-infrared images. Both patients presented with flu-like fever and sudden onset of fortifications within 48 hours of vaccination. One patient showed altered flow in the deep capillary plexus and highly elevated thrombotic parameters. Conclusion: We report a possible association between immune-mediated AMN and the administration of adenovirus-based COVID-19 vaccine Vaxzevria.
引用
收藏
页码:1234 / 1239
页数:6
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