Human CD8+ T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia

被引：67
|
作者：
Smith, SM
Klein, MR
Malin, AS
Sillah, J
Huygen, K
Andersen, P
McAdam, KPWJ
Dockrell, HM
机构：
[1] Univ London London Sch Hyg & Trop Med, Immunol Unit, London WC1E 7HT, England
[2] MRC Labs, TB Res Programme, Fajara, Gambia
[3] Inst Pasteur, Brussels, Belgium
[4] Statens Serum Inst, Dept TB Immunol, DK-2300 Copenhagen, Denmark
来源：
INFECTION AND IMMUNITY | 2000年 / 68卷 / 12期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/IAI.68.12.7144-7148.2000
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Intracellular flow cytometry analysis of perforin production by CD8(+) T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8(+) T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.
引用
收藏
页码：7144 / 7148
页数：5
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