Facile synthesis of silver doped-copper oxide nano materials utilizing areca catechu (AC) leaf extract and their antidiabetic and anticancer studies

被引:6
|
作者
Shwetha, U. R. [1 ]
Alnuwaiser, Maha Abdallah [2 ]
Latha, M. S. [3 ]
Betageri, Virupaxappa S. [1 ]
Shilpa, V. A. [1 ]
Khan, M. Ijaz [4 ,5 ]
Guedri, Kamel [6 ]
机构
[1] GM Inst Technol, Res Ctr, Dept Chem, Davangere 577006, Karnataka, India
[2] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Chem, POB 84428, Riyadh 11671, Saudi Arabia
[3] R L Sci Inst, Dept Chem, Belagavi 590001, Karnataka, India
[4] Peking Univ, Coll Engn, Lab Syst Ecol & Sustainabil Sci, Beijing 100871, Peoples R China
[5] Riphah Int Univ, Dept Math & Stat, I-14, Islamabad 44000, Pakistan
[6] Umm Al Qura Univ, Coll Engn & Islamic Architecture, Mech Engn Dept, POB 5555, Mecca 21955, Saudi Arabia
关键词
Green synthesis; DopedAg-CuO NPs; Solution combustion synthesis; Antidiabetic; Anticancer; CHLORIDE NANOPARTICLES; ANTIFUNGAL ACTIVITY; ANTIOXIDANT;
D O I
10.1016/j.jics.2022.100606
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The present research highlights physical significance of green combination of metal oxide nanomaterials utilizing medicinal plant which has widely analyzed in different medical applications i.e., medicinal science, therapeutics. In this paper, we discussed environmentally benign approach for synthesizing silver doped copper oxide nano -particles (Ag-CuO NPs) utilizing (ACLE). Scanning electron microscopy (SEM), X-ray diffraction (XRD), trans-mission electron microscopy (TEM) and energy dispersive spectroscopy (EDS) were utilized to confirm the size, crystalline structure and surface morphology of the obtained nanomaterials. The monoclinic crystalline structure of the Ag-CuO NPs as produced was revealed by XRD patterns. Morphological analysis disclosed the nano-based spherical configuration of Ag-CuO NPs, as well as their morphology and elemental composition. The anti -diabetic effect of Ag-CuO NPs was further investigated utilizing a yeast cell model and amylase inhibition. Here, a decrease in intracellular glucose and a delay in carbohydrate digestion indicate promising antidiabetic action. Furthermore, the prepared nanomaterial showed anticancer potential against the MCF-7 cancer cell line, with an IC 50 value of 11.21 g/ml.
引用
收藏
页数:6
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