Abundant human β-defensin-1 expression in milk and mammary gland epithelium

被引：79
|
作者：
Jia, HP
Starner, T
Ackermann, M
Kirby, P
Tack, BF
McCray, PB [1 ]
机构：
[1] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USA
[3] Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USA
[4] Iowa State Univ, Dept Vet Pathol, Ames, IA USA
来源：
JOURNAL OF PEDIATRICS | 2001年 / 138卷 / 01期
关键词：
D O I：
10.1067/mpd.2001.109375
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Human beta -defensin-1 (HBD-1) was detected in breast milk in concentrations of similar to1 to 10 mug/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The peptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 may augment neonatal host defenses through antimicrobial effects or prime the adaptive immune system at mucosal surfaces.
引用
收藏
页码：109 / 112
页数：4
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