Cross-Coupling Reactions of Monosubstituted Tetrazines

被引：11

作者：

Hoff, Lukas, V ^{[1
]}

Schnell, Simon D. ^{[1
]}

Tomio, Andrea ^{[1
]}

Linden, Anthony ^{[1
]}

Gademann, Karl ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 15期

关键词：

DIELS-ALDER REACTIONS; REDUCTIVE ELIMINATION; OXIDATIVE ADDITION; ARYL HALIDES; C-H; PALLADIUM;

D O I：

10.1021/acs.orglett.1c01813

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Ag-mediated Pd-catalyzed cross-coupling method for 3-bromo-1,2,4,5-tetrazine with boronic acids is presented. Electronic modification of the 1,1'-bis(diphenylphosphine)ferrocene (dppf) ligand was found to be crucial for good turnover. Using this fast method, a variety of alkyl-, heteroatom-, and halide-substituted aryl-and heteroaryl-tetrazines were prepared (29 examples, up to 87% yield).

引用

页码：5689 / 5692

页数：4

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