The combined impact of donor age and acute rejection on long-term cadaver renal allograft survival

Background: Acute rejection (AR) is an important risk factor for long-term renal graft loss. Furthermore, donor age is also associated with graft outcome. We analyzed the combined effects of cadaver donor. age and AR on long-term gr-aft survival. Methods: A retrospective review was made of 112 cadaver renal transplants at a single center Only grafts functioning at least 3 months were included in this analysis. Results: The 3-year survival of AR-free grafts was superior to that of grafts with An (98 % vs 67%, P <.001). Within the AR cohort donor age >50 years (P <.05) had nit additional negative impact on graft survival. The 3-year survival of nit older donor graft with AR was 33 % versus 82 % for a younger donor graft with AR. Conclusions: AR was a significant predictor of long-ton graft loss. Older donor kidneys with AX had poorer graft survival than did younger donor kidneys with AX.