DIABETES STATUS AND RACE ARE ASSOCIATED WITH CARDIOVASCULAR RISK MARKERS IN OBESE ADOLESCENTS

Objective: The objective of this study was to evaluate differences in cardiovascular disease (CVD) risk markers in obese adolescents based on diabetes status and race in order to improve risk-reduction intervention strategies. Methods: This was a retrospective, cross-sectional study of obese adolescents, age 10 to 21 years, who were evaluated at Children's of Alabama between 2000 and 2012. Subjects were classified by glycated hemoglobin (HbA(1c)) as having normoglycemia, prediabetes, or type 2 diabetes mellitus (T2DM). Results: There were a total of 491 African American (AA) or Caucasian American (CA) subjects. Body mass index was not different between HbA(1c) and racial groups. Compared to subjects with normoglycemia or prediabetes, subjects with T2DM had higher levels of total cholesterol (TC) (178.6 +/- 43.8 mg/dL vs. 161.5 +/- 32.5 mg/dL vs. 162.4 +/- 30.6 mg/dL; P<.0001) and low-density-lipoprotein cholesterol (107.4 +/- 39.2 mg/dL vs. 97.0 +/- 31.0 mg/dL vs. 97.5 +/- 26.9 mg/dL; P =.0073). Compared with AA subjects, CA subjects had lower high-density-lipoprotein cholesterol (HDL-C) levels (40.4 +/- 10.4 mg/dL vs. 44.3 +/- 11.9 mg/dL; P = .0005) and higher non-HDL-C levels (129.6 +/- 36.2 mg/dL vs. 122.5 +/- 37.5 mg/dL; P = .0490). Of the characteristics studied, HbA(1c) had the most significant positive association with dyslipidemia and was strongly correlated with both TC (beta, 4.21; P<.0001) and non-HDL-C (beta, 4.3; P<.0001). Conclusion: Obese adolescents with T2DM have more abnormal lipoprotein profiles than those with normoglycemia or prediabetes. Obese CA adolescents have more abnormal lipids than obese AA adolescents. HbA(1c) was the characteristic most highly associated with abnormal lipoprotein profiles in our subjects. Our results show that CVD risk markers in obese adolescents vary by race and HbA(1c) concentration.